GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs73201462 | 1 | rs6783253 | chr3:127851561 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.47 | 9.77E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs13191362 | 1 | rs67840803 | chr6:163049048 | PACRG | chr6:163148164-163736523:+ | 0.53 | 7.55 | 2.2E-13 | Body mass index |
| THCA | cis | rs73201462 | 1 | rs6784159 | chr3:127843378 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.62 | 5.04E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs9876781 | 1 | rs6784322 | chr3:48422235 | ATRIP | chr3:48488141-48507708:+ | 0.17 | 3.78 | 0.000175 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6784322 | chr3:48422235 | TREX1 | chr3:48501186-48509043:+ | -0.25 | -5.79 | 1.28E-8 | Longevity |
| THCA | cis | rs12638253 | 1 | rs6784421 | chr3:156655494 | LEKR1 | chr3:156544076-156763918:+ | 0.31 | 8.62 | 9.96E-17 | Multiple sclerosis (severity) |
| THCA | cis | rs12107539 | 1 | rs6784934 | chr3:151039018 | GPR87 | chr3:151011876-151034636:- | 0.21 | 4.64 | 4.43E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs6784934 | chr3:151039018 | P2RY14 | chr3:150929905-150996230:- | -0.2 | -4.32 | 1.89E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs10935120 | 1 | rs6785027 | chr3:134211649 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.7 | 4.73E-32 | Height |
| THCA | cis | rs10935120 | 1 | rs6785027 | chr3:134211649 | CEP63 | chr3:134204575-134293852:+ | -0.29 | -6.44 | 2.89E-10 | Height |
| THCA | cis | rs7647973 | 1 | rs6785045 | chr3:49435243 | GMPPB | chr3:49758932-49761384:- | 0.17 | 3.83 | 0.000148 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6785045 | chr3:49435243 | P4HTM | chr3:49027341-49044579:+ | -0.17 | -4.29 | 2.19E-5 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6785045 | chr3:49435243 | WDR6 | chr3:49044637-49053386:+ | 0.17 | 3.59 | 0.000359 | Menarche (age at onset) |
| THCA | cis | rs1552244 | 1 | rs67852463 | chr3:10157205 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.44 | 1.1E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs67852463 | chr3:10157205 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.37 | 1.53E-5 | Alzheimer's disease |